According to an article that appeared on the CBS News website, researchers are not sure why PPIs could result in kidney damage. One theory is that PPIs reduce the level of magnesium in the body, which could adversely affect the kidneys. Another is that PPIs could result in kidney inflammation, which, over time, could lead to severe problems as more PPIs are taken.
The kidneys serve the function of filtering excess fluids and waste from the blood, which is then eliminated through urine. Chronic kidney disease results in the accumulation of dangerous waste, electrolytes and fluid. Many patients suffering from this problem eventually have to go on dialysis or even have a kidney transplant.
- Back discomfort
- High blood pressure
- Inflammation of the ankles and feet
- Urination changes
These extremely popular medications could cause severe damage to the kidneys, according to an article that appeared on the CNN.com website. On April 14, 2016, the Journal of the American Society of Nephrology published a study that revealed people who take PPIs are at a significantly increased risk of kidney failure and kidney disease. A January 2016 study in JAMA (The Journal of the American Medical Association) Internal Medicine also showed a link between PPIs and chronic kidney disease.
According to CNN, researchers conducting the JAMA study analyzed more than 10,000 patients’ medical records and found that the ones who took PPIs were anywhere from 20 to 50 percent more likely to develop kidney disease than patients who did not take PPIs. They then looked at nearly 250,000 other records of patients in Pennsylvania hospitals and found a link between PPIs and kidney disease as well.
The article also reported the results of another study that analyzed nearly 175,000 patients who used PPIs and compared data from more than 20,000 others who took histamine H2 receptor blockers, an alternative to PPIs. The study showed that people who took PPIs were 96 percent more likely to develop kidney failure, and 28 percent more likely to develop chronic kidney disease, than those who took histamine H2.